Introduction: Benign prostatic hyperplasia (BPH) is a histological diagnosis characterized by an increase in the number of epithelial and stromal cells in the transitional zone of the prostate gland. The clinical manifestation of BPH is associated with the appearance of so-called lower urinary tract symptoms (LUTS) which can also be a consequence of other conditions not related to the prostate. Covid-19, also known as severe acute respiratory syndrome coronavirus 2 was discovered as a disease in late 2019 in the city of Wuhan, China. Materials and Methods: A case-control study was conducted between September 2021 and May 2022. Information was initially collected on 60 patients followed up and treated conservatively for BPH in two outpatient practices and recovered from Covid-19. After processing the received information, 27 patients were excluded from the study and 33 patients remained for observation The assessment of patients is carried out through an internationally validated questionnaire – international prostate symptom score (IPPS), prostate specific antigen, digital rectal examination (DRЕ), and ultrasound diagnostics of the prostate gland with consideration of its volume and the amount of residual urine. Results: Our data show a strong correlation between the changes in LUTS in patients with BPH and Covid-19 infection. Conclusion: Although almost 3 years have passed since the beginning of this pandemic, there are still many unanswered questions surrounding this disease. We believe that with our experience we will enrich the information about the relationship between Covid-19 and LUTS, and the results obtained by us can serve as a basis for future large-scale and more in-depth studies on the subject.

1.
Foo
KT
.
Pathophysiology of clinical benign prostatic hyperplasia
.
Asian J Urol
.
2017
;
4
(
3
):
152
7
.
2.
Lepor
H
.
Pathophysiology of lower urinary tract symptoms in the aging male population
.
Rev Urol
.
2005
;
7
(
Suppl 7
):
S3
11
.
3.
Roehrborn
CG
.
Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH)
.
Med Clin North Am
.
2011
;
95
(
1
):
87
100
.
4.
Porru
D
,
Jallous
H
,
Cavalli
V
,
Sallusto
F
,
Rovereto
B
.
Prognostic value of a combination of IPSS, flow rate and residual urine volume compared to pressure-flow studies in the preoperative evaluation of symptomatic BPH
.
Eur Urol
.
2002
;
41
(
3
):
246
9
.
5.
Puliatti
S
,
Eissa
A
,
Eissa
R
,
Amato
M
,
Mazzone
E
,
Dell’Oglio
P
,
.
COVID-19 and urology: a comprehensive review of the literature
.
BJU Int
.
2020
;
125
(
6
):
E7
14
.
6.
Huang
C
,
Wang
Y
,
Li
X
,
Ren
L
,
Zhao
J
,
Hu
Y
,
.
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
.
Lancet
.
2020
;
395
(
10223
):
497
506
.
7.
Partin
AW
,
Oesterling
JE
,
Epstein
JI
,
Horton
R
,
Walsh
PC
.
Influence of age and endocrine factors on the volume of benign prostatic hyperplasia
.
J Urol
.
1991 Feb
;
145
(
2
):
405
9
.
8.
Karavitakis
M
,
Kyriazis
I
,
Omar
MI
,
Gravas
S
,
Cornu
JN
,
Drake
MJ
,
.
Management of urinary retention in patients with benign prostatic obstruction: a systematic review and meta-analysis
.
Eur Urol
.
2019 May
;
75
(
5
):
788
98
.
9.
Sighinolfi
MC
,
Rocco
B
,
Mussini
C
.
COVID-19: importance of the awareness of the clinical syndrome by urologists
.
Eur Urol
.
2020
;
78
(
1
):
e40
e41
.
10.
Cohn
JN
.
Role of the renin-angiotensin system in cardiovascular disease
.
Cardiovasc Drugs Ther
.
2010
;
24
:
341
4
.
11.
Dinh
DT
,
Frauman
AG
,
Somers
GR
,
Ohishi
M
,
Zhou
J
,
Casley
DJ
,
.
Evidence for activation of the renin – angiotensin system in the human prostate: increased angiotensin II and reduced AT1 receptor expression in benign prostatic hyperplasia
.
J Pathol
.
2002
;
196
(
2
):
213
9
.
12.
Chughtai
B
,
Lee
R
,
Te
A
,
Kaplan
S
.
Role of inflammation in benign prostatic hyperplasia
.
Rev Urol
.
2011
;
13
(
3
):
147
50
.
13.
Chai
X
,
Hu
L
,
Zhang
Y
,
Han
W
,
Lu
Z
,
Ke
A
,
.
Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection
.
bioRxiv
.
2020
.
14.
Izumi
K
,
Mizokami
A
,
Lin
WJ
,
Lai
KP
,
Chang
C
.
Androgen receptor roles in the development of benign prostate hyperplasia
.
Am J Pathol
.
2013
;
182
(
6
):
1942
9
.
15.
Wambier
CG
,
Goren
A
.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated
.
J Am Acad Dermatol
.
2020
;
83
(
1
):
308
9
.
16.
Breyer
BN
,
Sarma
AV
.
Hyperglycemia and insulin resistance and the risk of BPH/LUTS: an update of recent literature
.
Curr Urol Rep
.
2014
;
15
(
12
):
462
.
17.
Sevim
M
,
Alkiş
O
,
Kartal
İG
,
Coşer
Ş
,
Akman
H
,
Aras
B
.
Impact of COVID-19 on the progression of benign prostatic hyperplasia and aggravation of related symptoms: a prospective study
.
Prostate
.
2023
;
83
(
1
):
82
6
.
18.
Nabeeh
H
,
Ibrahim
A
,
Taha
DE
,
Talaat
M
,
Abdelbaky
TM
.
Impact of COVID-19 pandemic on lower urinary tract symptoms in patients with benign prostatic hyperplasia and predictors of urine retention in such patients
.
Low Urin Tract Symptoms
.
2022 Jan
;
14
(
1
):
41
6
.
19.
Marand
AJB
,
Bach
C
,
Janssen
D
,
Heesakkers
J
,
Ghojazadeh
M
,
Vögeli
TA
,
.
Lower urinary tract signs and symptoms in patients with COVID-19
.
BMC Infect Dis
.
2021 Jul 26
;
21
(
1
):
706
.
You do not currently have access to this content.