Introduction: The aim of the study was to evaluate the effectiveness of a modified transvesical obturator nerve block (ONB) in the prevention of obturator nerve reflex and consecutive bladder perforations (BPs) during transurethral resection of bladder tumors (TURBTs). Materials and Methods: A retrospective analysis of all patients resected in 2014–2015 due to a bladder tumor of the lateral walls, including a follow-up period until December 2018, was performed. Two groups were defined: in the first group, all patients underwent TURBT with a modified transvesical ONB. The second group underwent conventional TURBT with intermittent resection. Primary endpoints were the rates of adductor contractions and BPs. Results: Ninety-four out of 1,145 resected patients presented with tumors on the lateral wall of the bladder and a complete dataset including a long-term follow-up. Thirty-six patients were treated in the ONB group, and 58 patients comprised the control group. The median age in the 2 groups was 70.8 and 71.8 years in the first and second groups, respectively. Adductor spasms were reported in 8.33 versus 25.86% (p = 0.057) and perforation in 2.78 versus 17.24% (p = 0.047) in groups 1 and 2, respectively. After a median follow-up of 32.5 months, there was no significant difference in recurrence rates (52.78 vs. 51.72%, p = 0.672). In a subgroup analysis, lower perforation rates were recorded for the ONB group in patients with tumors <3 cm (0/30 vs. 8/46, p = 0.076) and in patients with unifocal tumors (0/12 vs. 5/23, p = 0.141). Discussion/Conclusion: The simplified approach of transvesical ONB demonstrated in this study appears to be an inexpensive, safe, effective, and simple-to-use technique.

1.
Antoni
S
,
Ferlay
J
,
Soerjomataram
I
,
Znaor
A
,
Jemal
A
,
Bray
F
.
Bladder cancer incidence and mortality: a global overview and recent trends
.
Eur Urol
.
2017 Jan
;
71
(
1
):
96
108
. .
2.
Babjuk
M
,
Bohle
A
,
Burger
M
,
Capoun
O
,
Cohen
D
,
Comperat
EM
,
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016
.
Eur Urol
.
2017 Mar
;
71
(
3
):
447
61
.
3.
Dick
A
,
Barnes
R
,
Hadley
H
,
Bergman
RT
,
Ninan
CA
.
Complications of transurethral resection of bladder tumors: prevention, recognition and treatment
.
J Urol
.
1980 Dec
;
124
(
6
):
810
1
. .
4.
Collado
A
,
Chéchile
GE
,
Salvador
J
,
Vicente
J
.
Early complications of endoscopic treatment for superficial bladder tumors
.
J Urol
.
2000 Nov
;
164
(
5
):
1529
32
. .
5.
Traxer
O
,
Pasqui
F
,
Gattegno
B
,
Pearle
MS
.
Technique and complications of transurethral surgery for bladder tumours
.
BJU Int
.
2004 Sep
;
94
(
4
):
492
6
. .
6.
Balbay
MD
,
Cimentepe
E
,
Unsal
A
,
Bayrak
O
,
Koç
A
,
Akbulut
Z
.
The actual incidence of bladder perforation following transurethral bladder surgery
.
J Urol
.
2005 Dec
;
174
(
6
):
2260
3
; discussion 2262–3. .
7.
Comploj
E
,
Dechet
CB
,
Mian
M
,
Trenti
E
,
Palermo
S
,
Lodde
M
,
Perforation during TUR of bladder tumours influences the natural history of superficial bladder cancer
.
World J Urol
.
2014 Oct
;
32
(
5
):
1219
23
.
8.
Panagoda
PI
,
Vasdev
N
,
Gowrie-Mohan
S
.
Avoiding the obturator jerk during TURBT
.
Curr Urol
.
2018 Oct
;
12
(
1
):
1
5
. .
9.
Sugihara
T
,
Yasunaga
H
,
Horiguchi
H
,
Matsui
H
,
Nishimatsu
H
,
Nakagawa
T
,
Comparison of perioperative outcomes including severe bladder injury between monopolar and bipolar transurethral resection of bladder tumors: a population based comparison
.
J Urol
.
2014 Nov
;
192
(
5
):
1355
9
.
10.
Zhao
C
,
Tang
K
,
Yang
H
,
Xia
D
,
Chen
Z
.
Bipolar versus monopolar transurethral resection of nonmuscle-invasive bladder cancer: a meta-analysis
.
J Endourol
.
2016 Jan
;
30
(
1
):
5
12
. .
11.
Venkatramani
V
,
Panda
A
,
Manojkumar
R
,
Kekre
NS
.
Monopolar versus bipolar transurethral resection of bladder tumors: a single center, parallel arm, randomized, controlled trial
.
J Urol
.
2014 Jun
;
191
(
6
):
1703
7
. .
12.
Liem
E
,
McCormack
M
,
Chan
ESY
,
Matsui
Y
,
Geavlete
P
,
Choi
YD
,
Monopolar vs. bipolar transurethral resection for non-muscle invasive bladder carcinoma: a post-hoc analysis from a randomized controlled trial
.
Urol Oncol
.
2018 Jul
;
36
(
7
):
338.e1
e11
.
13.
Khorrami
MH
,
Javid
A
,
Saryazdi
H
,
Javid
M
.
Transvesical blockade of the obturator nerve to prevent adductor contraction in transurethral bladder surgery
.
J Endourol
.
2010 Oct
;
24
(
10
):
1651
4
. .
14.
Khorrami
M
,
Hadi
M
,
Javid
A
,
Izadpahani
MH
,
Mohammadi Sichani
M
,
Zargham
M
,
A comparison between blind and nerve stimulation guided obturator nerve block in transurethral resection of bladder tumor
.
J Endourol
.
2012 Oct
;
26
(
10
):
1319
22
.
15.
Mariappan
P
,
Zachou
A
,
Grigor
KM
;
Edinburgh Uro-Oncology Group
.
Detrusor muscle in the first, apparently complete transurethral resection of bladder tumour specimen is a surrogate marker of resection quality, predicts risk of early recurrence, and is dependent on operator experience
.
Eur Urol
.
2010 May
;
57
(
5
):
843
9
.
16.
Mariappan
P
,
Finney
SM
,
Head
E
,
Somani
BK
,
Zachou
A
,
Smith
G
,
Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking
.
BJU Int
.
2012 Jun
;
109
(
11
):
1666
73
.
17.
Lazica
DA
,
Bottcher
S
,
Degener
S
,
von Rundstedt
FC
,
Brandt
AS
,
Storkel
S
,
[T1 bladder cancer: role of documentation for bladder tumor findings and targeted second resection]
.
Urologe A
.
2013 Aug
;
52
(
8
):
1110
7
.
18.
Woldu
SL
,
Bagrodia
A
,
Lotan
Y
.
Guideline of guidelines: non-muscle-invasive bladder cancer
.
BJU Int
.
2017 Mar
;
119
(
3
):
371
80
. .
19.
Zainfeld
D
,
Daneshmand
S
.
Transurethral resection of bladder tumors: improving quality through new techniques and technologies
.
Curr Urol Rep
.
2017 May
;
18
(
5
):
34
. .
20.
Leyh
H
.
[Transurethral electroresection of the urinary bladder (TURB)]
.
Aktuelle Urol
.
2014 Mar
;
45
(
2
):
148
57
. .
21.
Faul
F
,
Erdfelder
E
,
Lang
AG
,
Buchner
AG
.
*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences
.
Behav Res Methods
.
2007 May
;
39
(
2
):
175
91
.
22.
Golan
S
,
Baniel
J
,
Lask
D
,
Livne
PM
,
Yossepowitch
O
.
Transurethral resection of bladder tumour complicated by perforation requiring open surgical repair: clinical characteristics and oncological outcomes
.
BJU Int
.
2011 Apr
;
107
(
7
):
1065
8
. .
23.
Pladzyk
K
,
Jureczko
L
,
Lazowski
T
.
Over 500 obturator nerve blocks in the lithotomy position during transurethral resection of bladder tumor
.
Cent European J Urol
.
2012
;
65
(
2
):
67
70
. .
24.
Carpenter
RL
,
Caplan
RA
,
Brown
DL
,
Stephenson
C
,
Wu
R
.
Incidence and risk factors for side effects of spinal anesthesia
.
Anesthesiology
.
1992 Jun
;
76
(
6
):
906
16
. .
25.
Hebl
JR
,
Horlocker
TT
,
Kopp
SL
,
Schroeder
DR
.
Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications
.
Anesth Analg
.
2010 Dec
;
111
(
6
):
1511
9
. .
26.
Liu
SS
,
Strodtbeck
WM
,
Richman
JM
,
Wu
CL
.
A comparison of regional versus general anesthesia for ambulatory anesthesia: a meta-analysis of randomized controlled trials
.
Anesth Analg
.
2005 Dec
;
101
(
6
):
1634
42
. .
27.
Repici
A
,
Hassan
C
,
Pagano
N
,
Rando
G
,
Romeo
F
,
Spaggiari
P
,
High efficacy of endoscopic submucosal dissection for rectal laterally spreading tumors larger than 3 cm
.
Gastrointest Endosc
.
2013 Jan
;
77
(
1
):
96
101
.
28.
Balmadrid
B
,
Hwang
JH
.
Endoscopic resection of gastric and esophageal cancer
.
Gastroenterol Rep
.
2015 Nov
;
3
(
4
):
330
8
. .
29.
Cheng
YY
,
Sun
Y
,
Li
J
,
Liang
L
,
Zou
TJ
,
Qu
WX
,
Transurethral endoscopic submucosal en bloc dissection for nonmuscle invasive bladder cancer: a comparison study of HybridKnife-assisted versus conventional dissection technique
.
J Cancer Res Ther
.
2018
;
14
(
7
):
1606
12
.
30.
Patel
D
,
Shah
B
,
Pate
B
.
Contribution of the obturator nerve block in the trans urethral resection of bladder tumours
.
Indian J Anaesth
.
2004
;
48
(
1
):
47
9
.
31.
Tekgul
ZT
,
Divrik
RT
,
Turan
M
,
Konyalioglu
E
,
Simsek
E
,
Gonullu
M
.
Impact of obturator nerve block on the short-term recurrence of superficial bladder tumors on the lateral wall
.
Urol J
.
2014
;
11
(
1
):
1248
52
.
32.
Bolat
D
,
Aydogdu
O
,
Tekgul
ZT
,
Polat
S
,
Yonguc
T
,
Bozkurt
IH
,
Impact of nerve stimulator-guided obturator nerve block on the short-term outcomes and complications of transurethral resection of bladder tumour: A prospective randomized controlled study
.
Can Urol Assoc J
.
2015
;
9
(
11–12
):
E780
-
784
.
33.
Erbay
G
,
Akyol
F
,
Karabakan
M
,
Celebi
B
,
Keskin
E
,
Hirik
E
.
Effect of obturator nerve block during transurethral resection of lateral bladder wall tumors on the presence of detrusor muscle in tumor specimens and recurrence of the disease
.
Kaohsiung J Med Sci
.
2017
;
33
(
2
):
86
90
.
34.
Alavi
CE
,
Asgari
SA
,
Falahatkar
S
,
Rimaz
S
,
Naghipour
M
,
Khoshrang
H
,
Effectiveness of spinal anesthesia combined with obturator nerve blockade in preventing adductor muscle contraction during transurethral resection of bladder tumor
.
Turk J Urol
.
2017
;
43
(
4
):
507
11
.
35.
Abourjila
G
,
Noh
E
.
Effect of obturator nerve block during transurethral resection of lateral bladder wall tumors: a comparison of monopolar and bipolar TUR-BT regarding the presence of detrusor muscle in tumor specimens and recurrence of disease
.
JMSR. DOI: 10.4103/JMISR.JMISR_77_19
. .
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