Abstract
Synovial sarcomas occur predominantly in the extremities. Primary renal synovial sarcoma is a rare entity. Very few cases have been reported in the literature. Clinical and radiological features are similar to renal cell carcinoma with the diagnosis being established after surgery based on histopathology, immunohistochemistry, and chromosome studies. There are no established guidelines on the role of adjuvant treatment in the management of this disease. We herein present a series of 3 cases managed at 2 institutions. In the current series, all patients had venous thrombus, and surgery was the mainstay of treatment. One patient received neoadjuvant chemotherapy after a preoperative biopsy which was done as she did not respond to chemotherapy for a presumptive diagnosis of Wilm’s tumor.
References
1.
Paláu
LMA
, Thu Pham
T
, Barnard
N
, Merino
MJ
. Primary synovial sarcoma of the kidney with rhabdoid features
. Int J Surg Pathol
. 2007 Oct
;15
(4
):421
–8
.2.
Gulum
M
, Yeni
E
, Savas
M
, Ozardali
I
, Ozdemir
I
, Mil
D
, Primary renal synovial sarcoma
. Case Rep Urol
. 2011 Aug 11
;2011
:1
. .3.
Argani
P
, Faria
PA
, Epstein
JI
, Reuter
VE
, Perlman
EJ
, Beckwith
JB
, Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney
. Am J Surg Pathol
. 2000 Aug
;24
(8
):1087
–96
. .4.
Farrow
GM
, Harrison
EG
Jr, Utz
DC
. Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. 3
. Cancer
. 1968 Sep
;22
(3
):556
–63
. .5.
Ozkan
EE
, Mertsoylu
H
, Ozardali
HI
. A case of renal synovial sarcoma treated with adjuvant ifosfamide and doxorubicin
. Intern Med
. 2011
;50
(15
):1575
–80
. .6.
Dutt
UK
, Manikandan
R
, Dorairajan
LN
, Srinivas
BH
. Biphasic renal synovial sarcoma with extensive venous tumor thrombosis: a rare presentation
. Urol Ann
. 2018 Jul
;10
(3
):339
. .7.
Karavasilis
V
, Seddon
BM
, Ashley
S
, Al‐Muderis
O
, Fisher
C
, Judson
I
. Significant clinical benefit of first‐line palliative chemotherapy in advanced soft‐tissue sarcoma: retrospective analysis and identification of prognostic factors in 488 patients
. Cancer
. 2008 Apr 1
;112
(7
):1585
–91
.8.
Park
SJ
, Kim
HK
, Kim
CK
, Park
SK
, Go
ES
, Kim
ME
, A case of renal synovial sarcoma: complete remission was induced by chemotherapy with doxorubicin and ifosfamide
. Korean J Intern Med
. 2004 Mar
;19
(1
):62
. .9.
Bakhshi
GD
, Khan
AS
, Shaikh
AS
, Khan
MA
, Khan
MA
, Jamadar
NM
. Primary renal synovial sarcoma
. Clin Pract
. 2012 Feb
;2
(2
):e44
–6
. .10.
Kawai
A
, Woodruff
J
, Healey
JH
, Brennan
MF
, Antonescu
CR
, Ladanyi
M
. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma
. N Engl J Med
. 1998 Jan 15
;338
(3
):153
–60
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