Introduction: To compare RENAL, preoperative aspects and dimensions used for an anatomical (PADUA) classification, and Mayo Adhesive Probability (MAP) scores with the respective intraoperative findings and surgeon’s assessment in predicting surgical outcome of patients undergoing partial nephrectomy. Methods: Data of 150 eligible patients treated at the University Medical Center Mannheim between 2016 and 2018 were analyzed. Tumors were radiologically and intraoperatively assessed by PADUA, RENAL, and MAP scores and surgeon’s assessment. Correlations and regression models were created to predict ischemia time (IT), major complications, and Trifecta (negative surgical margin, IT < 25 min, and absence of major complications). Results: There were strong correlations between radiological and intraoperative RENAL (r = 0.68; p < 0.001) and PADUA scores (r = 0.72; p < 0.001). Radiological RENAL, PADUA, and MAP scores and surgeon’s assessment were independent predictors of Trifecta (OR = 0.71, p = 0.015; OR = 0.77, p = 0.035; OR = 0.65, p = 0.012; OR = 0.40, p = 0.005, respectively). IT showed significant associations with radiological RENAL, PADUA, and surgeon’s assessment (OR = 1.41, p = 0.033; OR = 1.34, p = 0.044; OR = 3.04, p = 0.003, respectively). MAP score proved as only independent predictor of major complications (OR = 2.12, p = 0.002). Conclusion: Radiologically and intraoperatively assessed scores correlated well with each other. Intraoperative nephrometry did not outperform radiological scores in predicting outcome confirming the value of the existing systems. MAP score correlates well with surgeon’s assessment of perirenal fat and major complications underlining the importance of perirenal fat characteristics.

1.
Van Poppel
H
,
Becker
F
,
Cadeddu
JA
,
Gill
IS
,
Janetschek
G
,
Jewett
MA
, et al.
Treatment of localised renal cell carcinoma
.
Eur Urol
.
2011 Oct
;
60
(
4
):
662
72
.
2.
Ljungberg
B
,
Bensalah
K
,
Canfield
S
,
Dabestani
S
,
Hofmann
F
,
Hora
M
, et al.
EAU guidelines on renal cell carcinoma: 2014 update
.
Eur Urol
.
2015 May
;
67
(
5
):
913
24
.
3.
Boy
A
,
Hein
J
,
Bollow
M
,
Lazica
D
,
Roosen
A
,
Ubrig
B
.
[Minimally invasive vs. open partial nephrectomy: perioperative success and complication rates]
.
Urologe A
.
2018 Jul
;
57
(
7
):
821
7
.
4.
Van Poppel
H
,
Da Pozzo
L
,
Albrecht
W
,
Matveev
V
,
Bono
A
,
Borkowski
A
, et al.
A prospective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma
.
Eur Urol
.
2007 Jun
;
51
(
6
):
1606
15
.
5.
Kriegmair
MC
,
Hetjens
S
,
Mandel
P
,
Wadle
J
,
Budjan
J
,
Michel
MS
, et al.
Tumor size and invasiveness matters for partial nephrectomy: external validation and modification of the arterial based complexity score
.
J Surg Oncol
.
2017 May
;
115
(
6
):
768
74
.
6.
Stühler
V
,
Kruck
S
,
Todenhöfer
T
,
Stenzl
A
,
Bedke
J
.
[Current guideline-oriented follow-up of small renal masses: applied risk scores and future outlook]
.
Der Urologe Ausg A
.
2018 Mar
;
57
(
3
):
300
6
.
7.
Klatte
T
,
Ficarra
V
,
Gratzke
C
,
Kaouk
J
,
Kutikov
A
,
Macchi
V
, et al.
A literature review of renal surgical anatomy and surgical strategies for partial nephrectomy
.
Eur Urol
.
2015 Dec
;
68
(
6
):
980
92
.
8.
Kutikov
A
,
Uzzo
RG
.
The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth
.
J Urol
.
2009 Sep
;
182
(
3
):
844
53
.
9.
Ficarra
V
,
Novara
G
,
Secco
S
,
Macchi
V
,
Porzionato
A
,
De Caro
R
, et al.
Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery
.
Eur Urol
.
2009 Nov
;
56
(
5
):
786
93
.
10.
Bylund
JR
,
Qiong
H
,
Crispen
PL
,
Venkatesh
R
,
Strup
SE
.
Association of clinical and radiographic features with perinephric “sticky” fat
.
J Endourol
.
2013 Mar
;
27
(
3
):
370
3
.
11.
Davidiuk
AJ
,
Parker
AS
,
Thomas
CS
,
Leibovich
BC
,
Castle
EP
,
Heckman
MG
, et al.
Mayo adhesive probability score: an accurate image-based scoring system to predict adherent perinephric fat in partial nephrectomy
.
Eur Urol
.
2014 Dec
;
66
(
6
):
1165
71
.
12.
Waldert
M
,
Waalkes
S
,
Klatte
T
,
Kuczyk
MA
,
Weibl
P
,
Schüller
G
, et al.
External validation of the preoperative anatomical classification for prediction of complications related to nephron-sparing surgery
.
World J Urol
.
2010 Aug
;
28
(
4
):
531
5
.
13.
Hew
MN
,
Baseskioglu
B
,
Barwari
K
,
Axwijk
PH
,
Can
C
,
Horenblas
S
, et al.
Critical appraisal of the PADUA classification and assessment of the R.E.N.A.L. nephrometry score in patients undergoing partial nephrectomy
.
J Urol
.
2011 Jul
;
186
(
1
):
42
6
.
14.
Long
JA
,
Arnoux
V
,
Fiard
G
,
Autorino
R
,
Descotes
JL
,
Rambeaud
JJ
, et al.
External validation of the RENAL nephrometry score in renal tumours treated by partial nephrectomy
.
BJU Int
.
2013 Feb
;
111
(
2
):
233
9
.
15.
Kriegmair
MC
,
Mandel
P
,
Moses
A
,
Lenk
J
,
Rothamel
M
,
Budjan
J
, et al.
Defining renal masses: comprehensive comparison of RENAL, PADUA, NePhRO, and C-index score
.
Clin Genitourin Cancer
.
2017
;
15
(
2
):
248
255.e1
.
16.
Schiavina
R
,
Novara
G
,
Borghesi
M
,
Ficarra
V
,
Ahlawat
R
,
Moon
DA
, et al.
PADUA and R.E.N.A.L. nephrometry scores correlate with perioperative outcomes of robot-assisted partial nephrectomy: analysis of the Vattikuti global quality initiative in robotic urologic surgery (GQI-RUS) database
.
BJU Int
.
2017
;
119
(
3
):
456
63
.
17.
Okhunov
Z
,
Rais-Bahrami
S
,
George
AK
,
Waingankar
N
,
Duty
B
,
Montag
S
, et al.
The comparison of three renal tumor scoring systems: C-Index, P.A.D.U.A., and R.E.N.A.L. nephrometry scores
.
J Endourol
.
2011 Dec
;
25
(
12
):
1921
4
.
18.
Simmons
MN
,
Hillyer
SP
,
Lee
BH
,
Fergany
AF
,
Kaouk
J
,
Campbell
SC
.
Nephrometry score is associated with volume loss and functional recovery after partial nephrectomy
.
J Urol
.
2012 Jul
;
188
(
1
):
39
44
.
19.
Zhang
ZY
,
Tang
Q
,
Li
XS
,
Zhang
Q
,
Mayer
WA
,
Wu
JY
, et al.
Clinical analysis of the PADUA and the RENAL scoring systems for renal neoplasms: a retrospective study of 245 patients undergoing laparoscopic partial nephrectomy
.
Int J Urol
.
2014 Jan
;
21
(
1
):
40
4
.
20.
Bylund
JR
,
Gayheart
D
,
Fleming
T
,
Venkatesh
R
,
Preston
DM
,
Strup
SE
, et al.
Association of tumor size, location, R.E.N.A.L., PADUA and centrality index score with perioperative outcomes and postoperative renal function
.
J Urol
.
2012 Nov
;
188
(
5
):
1684
9
.
21.
Sharma
AP
,
Mavuduru
RS
,
Bora
GS
,
Devana
SK
,
Singh
SK
,
Mandal
AK
.
Predicting trifecta outcomes after robot-assisted nephron-sparing surgery: beyond the nephrometry score
.
Investig Clin Urol
.
2018 Sep
;
59
(
5
):
305
12
.
22.
Clavien
PA
,
Barkun
J
,
de Oliveira
ML
,
Vauthey
JN
,
Dindo
D
,
Schulick
RD
, et al.
The Clavien-Dindo classification of surgical complications: five-year experience
.
Ann Surg
.
2009 Aug
;
250
(
2
):
187
96
.
23.
Khalifeh
A
,
Autorino
R
,
Hillyer
SP
,
Laydner
H
,
Eyraud
R
,
Panumatrassamee
K
, et al.
Comparative outcomes and assessment of trifecta in 500 robotic and laparoscopic partial nephrectomy cases: a single surgeon experience
.
J Urol
.
2013 Apr
;
189
(
4
):
1236
42
.
24.
Christensen
RH
,
Lundgren
T
,
Stenvinkel
P
,
Brismar
TB
.
Renal volumetry with magnetic resonance imaging
.
Acta Radiol Open
.
2017 Sep
;
6
(
9
):
2058460117731120
.
25.
Maurice
MJ
,
Ramirez
D
,
Malkoç
E
,
Kara
ÖO
,
Nelson
RJ
,
Caputo
PA
, et al.
Predictors of excisional volume loss in partial nephrectomy: is there still room for improvement?
Eur Urol
.
2016 Sep
;
70
(
3
):
413
5
.
26.
Taylor
R
.
Interpretation of the correlation coefficient: a basic review
.
J Diagn Med Sonogr
.
1990
;
6
(
1
):
35
9
.
27.
Karkouti
K
,
Djaiani
G
,
Borger
MA
,
Beattie
WS
,
Fedorko
L
,
Wijeysundera
D
, et al.
Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery
.
Ann Thorac Surg
.
2005
;
80
(
4
):
1381
7
.
28.
Lang
T
.
Documenting research in scientific articles: guidelines for authors: 3. Reporting multivariate analyses
.
Chest
.
2007
;
131
(
2
):
628
32
.
29.
Khene
ZE
,
Peyronnet
B
,
Freton
L
,
Graffeille
V
,
Pradere
B
,
Robert
C
, et al.
What is better for predicting morbidity of robotic partial nephrectomy-a score or your clinical judgement?
Eur Urol Focus
.
2020
;
6
(
2
):
313
9
.
30.
Harke
NN
,
Mandel
P
,
Witt
JH
,
Wagner
C
,
Panic
A
,
Boy
A
, et al.
Are there limits of robotic partial nephrectomy? TRIFECTA outcomes of open and robotic partial nephrectomy for completely endophytic renal tumors
.
J Surg Oncol
.
2018 Jul
;
118
(
1
):
206
11
.
31.
Khene
ZE
,
Peyronnet
B
,
Kocher
NJ
,
Robyak
H
,
Robert
C
,
Pradere
B
, et al.
Predicting morbidity after robotic partial nephrectomy: the effect of tumor, environment, and patient-related factors
.
Urol Oncol
.
2018 Jul
;
36
(
7
):
338
e26
.
32.
Sharma
AP
,
Mavuduru
RS
,
Bora
GS
,
Devana
SK
,
Palani
K
,
Lal
A
, et al.
Comparison of RENAL, PADUA, and C-index scoring systems in predicting perioperative outcomes after nephron sparing surgery
.
Indian J Urol
.
2018 Jan–Mar
;
34
(
1
):
51
5
.
33.
Acar
ÖO
,
Ozturk-IsikIsik
EEO
,
Mut
T
,
Sağlıcan
Y
,
Onay
A
,
Vural
M
, et al.
Erratum to: comparison of the trifecta outcomes of robotic and open nephron-sparing surgeries performed in the robotic era of a single institution
.
SpringerPlus
.
2015
;
4
:
664
.
34.
Mottrie
A
,
Schatteman
P
,
De Wil
P
,
De Troyer
B
,
Novara
G
,
Ficarra
V
.
Validation of the preoperative aspects and dimensions used for an anatomical (PADUA) score in a robot-assisted partial nephrectomy series
.
World J Urol
.
2013 Aug
;
31
(
4
):
799
804
.
35.
Borghesi
M
,
Della Mora
L
,
Brunocilla
E
,
Schiavina
R
,
Rizzi
S
,
La Manna
G
, et al.
Warm ischemia time and postoperative complications after partial nephrectomy for renal cell carcinoma
.
Actas Urol Esp
.
2014 Jun
;
38
(
5
):
313
8
.
36.
Simhan
J
,
Smaldone
MC
,
Tsai
KJ
,
Canter
DJ
,
Li
T
,
Kutikov
A
, et al.
Objective measures of renal mass anatomic complexity predict rates of major complications following partial nephrectomy
.
Eur Urol
.
2011 Oct
;
60
(
4
):
724
30
.
37.
Mufarrij
PW
,
Krane
LS
,
Rajamahanty
S
,
Hemal
AK
.
Does nephrometry scoring of renal tumors predict outcomes in patients selected for robot-assisted partial nephrectomy?
J Endourol
.
2011 Oct
;
25
(
10
):
1649
53
.
38.
Yeon
JS
,
Son
SJ
,
Lee
YJ
,
Cha
WH
,
Choi
WS
,
Chung
JW
, et al.
The nephrometry score: is it effective for predicting perioperative outcome during robot-assisted partial nephrectomy?
Korean J Urol
.
2014 Apr
;
55
(
4
):
254
9
.
39.
Dariane
C
,
Le Guilchet
T
,
Hurel
S
,
Audenet
F
,
Beaugerie
A
,
Badoual
C
, et al.
Prospective assessment and histological analysis of adherent perinephric fat in partial nephrectomies
.
Urol Oncol
.
2017 Feb
;
35
(
2
):
39
e17
.
40.
Lee
SM
,
Robertson
I
,
Stonier
T
,
Simson
N
,
Amer
T
,
Aboumarzouk
OM
.
Contemporary outcomes and prediction of adherent perinephric fat at partial nephrectomy: a systematic review
.
Scand J Urol
.
2017 Dec
;
51
(
6
):
1
6
.
41.
Kawamura
N
,
Saito
K
,
Inoue
M
,
Ito
M
,
Kijima
T
,
Yoshida
S
, et al.
Adherent perinephric fat in asian patients: predictors and impact on perioperative outcomes of partial nephrectomy
.
Urol Int
.
2018
;
101
(
4
):
437
42
.
42.
Thompson
RH
,
Lane
BR
,
Lohse
CM
,
Leibovich
BC
,
Fergany
A
,
Frank
I
, et al.
Renal function after partial nephrectomy: effect of warm ischemia relative to quantity and quality of preserved kidney
.
Urology
.
2012 Feb
;
79
(
2
):
356
60
.
43.
Simmons
MN
,
Lieser
GC
,
Fergany
AF
,
Kaouk
J
,
Campbell
SC
.
Association between warm ischemia time and renal parenchymal atrophy after partial nephrectomy
.
J Urol
.
2013 May
;
189
(
5
):
1638
42
.
44.
Anderson
BG
,
Potretzke
AM
,
Du
K
,
Vetter
JM
,
Bergeron
K
,
Paradis
AG
, et al.
Comparing off-clamp and on-clamp robot-assisted partial nephrectomy: a prospective randomized trial
.
Urology
.
2019
;
126
:
102
9
.
45.
Cacciamani
GE
,
Medina
LG
,
Gill
TS
,
Mendelsohn
A
,
Husain
F
,
Bhardwaj
L
, et al.
Impact of renal hilar control on outcomes of robotic partial nephrectomy: systematic review and cumulative meta-analysis
.
Eur Urol Focus
.
2019
;
5
(
4
):
619
35
.
46.
Kruck
S
,
Anastasiadis
AG
,
Walcher
U
,
Stenzl
A
,
Herrmann
TR
,
Nagele
U
.
Laparoscopic partial nephrectomy: risk stratification according to patient and tumor characteristics
.
World J Urol
.
2012 Oct
;
30
(
5
):
639
46
.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.