Objective: Inflammatory myofibroblastic tumors (IMTs) of the urinary system are relatively rare and often misdiagnosed. We aimed to summarize and analyze the clinical manifestations, imaging features, management, and follow-up of renal and bladder IMTs. Methods: In this retrospective study, 22 patients with IMT pathologically verified between 2009 and 2018 were included. Epidemiologic, clinical, pathologic, and imaging findings were recorded. Tumor size, location, and shape were analyzed and summarized. Results: There were 22 patients with a median age of 45 years (range: 20–74), including 14 patients with renal IMT and 8 patients with bladder IMT, who met the eligibility criteria. In 21 patients, IMT appeared as a single lesion, whereas 1 patient showed bilateral renal lesions. Surgical resection was the sole therapy, and follow-up information was acquired from 13 individuals with no evidence of recurrence or metastasis. In our study, a slightly hypodense or isodense homogeneous tumor with a clear boundary was more often seen. On contrast-enhanced computed tomography (CT), they were often manifesting as a slightly heterogeneous enhancement. Conclusions: The nature of IMTs might cause a lack of generalizability. However, it will be useful to know that there are various CT demonstrations of IMTs. CT images are useful for the detection, location, and characterization of urinary IMTs, which can help in better clinical decision-making and can also be an optimal imaging technique for follow-up.

1.
Surabhi
VR
,
Chua
S
,
Patel
RP
,
Takahashi
N
,
Lalwani
N
,
Prasad
SR
.
Inflammatory Myofibroblastic Tumors: current Update
.
Radiol Clin North Am
.
2016
May
;
54
(
3
):
553
63
.
[PubMed]
0033-8389
2.
Kapusta
LR
,
Weiss
MA
,
Ramsay
J
,
Lopez-Beltran
A
,
Srigley
JR
.
Inflammatory myofibroblastic tumors of the kidney: a clinicopathologic and immunohistochemical study of 12 cases
.
Am J Surg Pathol
.
2003
May
;
27
(
5
):
658
66
.
[PubMed]
0147-5185
3.
Park
SB
,
Cho
KS
,
Kim
JK
,
Lee
JH
,
Jeong
AK
,
Kwon
WJ
, et al.
Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract
.
AJR Am J Roentgenol
.
2008
Oct
;
191
(
4
):
1255
62
.
[PubMed]
0361-803X
4.
Liang
W
,
Zhou
X
,
Xu
S
,
Lin
S
.
CT Manifestations of Inflammatory Myofibroblastic Tumors (Inflammatory Pseudotumors) of the Urinary System
.
AJR Am J Roentgenol
.
2016
Jun
;
206
(
6
):
1149
55
.
[PubMed]
0361-803X
5.
Li
Z
,
Wang
W
,
Wang
Y
,
Zhai
X
,
Tian
Y
,
Fu
Y
, et al.
Inflammatory myofibroblastic tumor of the kidney with viral hepatitis B and trauma: A case report
.
Oncol Lett
.
2013
Dec
;
6
(
6
):
1741
3
.
[PubMed]
1792-1074
6.
Park
JJ
,
Jeong
BC
,
Kim
CK
,
Seo
SI
,
Carriere
KC
,
Kim
M
, et al.
Postoperative Outcome of Cystic Renal Cell Carcinoma Defined on Preoperative Imaging: A Retrospective Study
.
J Urol
.
2017
Apr
;
197
(
4
):
991
7
.
[PubMed]
0022-5347
7.
Harik
LR
,
Merino
C
,
Coindre
JM
,
Amin
MB
,
Pedeutour
F
,
Weiss
SW
.
Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases
.
Am J Surg Pathol
.
2006
Jul
;
30
(
7
):
787
94
.
[PubMed]
0147-5185
8.
Proppe
KH
 Sr
,
Scully
RE
,
Rosai
J
.
Postoperative spindle cell nodules of genitourinary tract resembling sarcomas. A report of eight cases
.
Am J Surg Pathol
.
1984
Feb
;
8
(
2
):
101
8
.
[PubMed]
0147-5185
9.
Hötker
AM
,
Karlo
CA
,
Zheng
J
,
Moskowitz
CS
,
Russo
P
,
Hricak
H
, et al.
Clear Cell Renal Cell Carcinoma: Associations Between CT Features and Patient Survival
.
AJR Am J Roentgenol
.
2016
May
;
206
(
5
):
1023
30
.
[PubMed]
0361-803X
10.
Hori
J
,
Komiyama
M
.
A case of inflammatory myofibroblastic tumor of the kidney with cystic change
.
Jpn J Clin Oncol
.
2009
Jun
;
39
(
6
):
410
.
[PubMed]
0368-2811
11.
Wang
Y
,
Qi
X
,
Xue
P
,
Zhang
C
,
Cai
C
,
Tu
C
, et al.
Inflammatory myofibroblastic tumors in the kidney and abdominal wall mimicking malignancy: A case report
.
Medicine (Baltimore)
.
2018
Aug
;
97
(
34
):
e11994
.
[PubMed]
0025-7974
12.
Bektas
S
,
Okulu
E
,
Kayigil
O
,
Ertoy Baydar
D
.
Inflammatory myofibroblastic tumor of the perirenal soft tissue misdiagnosed as renal cell carcinoma
.
Pathol Res Pract
.
2007
;
203
(
6
):
461
5
.
[PubMed]
0344-0338
13.
Nakamura
Y
,
Urashima
M
,
Nishihara
R
,
Matsuura
A
,
Bekku
K
,
Iguchi
H
, et al.
Inflammatory pseudotumor of the kidney with renal artery penetration
.
Radiat Med
.
2007
Dec
;
25
(
10
):
541
7
.
[PubMed]
0288-2043
14.
Kwang Ho Ryu
CM
.
Myung Ki Kim. Inflammatory Myofibroblastic Tumor of the Kidney Misdiagnosed as Renal Cell Carcinoma
.
Korean Med Sci
.
2010
;
25
(
2
):
330
2
.
15.
Sankineni
S
,
Brown
A
,
Cieciera
M
,
Choyke
PL
,
Turkbey
B
.
Imaging of renal cell carcinoma
.
Urol Oncol
.
2016
Mar
;
34
(
3
):
147
55
.
[PubMed]
1078-1439
16.
Ma
Y
,
Zieske
AW
,
Fenves
AZ
.
Bilateral infiltrating renal inflammatory pseudotumor responsive to corticosteroid therapy
.
Am J Kidney Dis
.
2008
Jan
;
51
(
1
):
116
20
.
[PubMed]
0272-6386
17.
Li
JY
,
Yong
TY
,
Coleman
M
,
Astill
D
,
Passaris
G
,
Juneja
R
, et al.
Bilateral renal inflammatory pseudotumour effectively treated with corticosteroid
.
Clin Exp Nephrol
.
2010
Apr
;
14
(
2
):
190
8
.
[PubMed]
1342-1751
18.
Mark
E
.
Williams, H. Estabrook Longmaid, Gary Trey, Micheline Federman, and Ann W. Crosson. Renal Failure Resulting From Infiltration by Inflammatory Myofiroblastic Tumor Responsive to Corticosteroid Therapy.pdf[{GT}]
.
Am J Kidney Dis
.
1998
;
31
(
6
):
E5
.
[PubMed]
0272-6386
19.
Tadao
K.
Kobayash MU, Toshihiro Nishino.et al. Inflammatory Pseudotumor of the Kidney: Report of a Case with Fine Needle Aspiration Cytology. The International Academy of Cytology Acta Cytologica Volume 44, Number 3/May–June
2000
20.
Ishikawa
T
,
Fujisawa
M
,
Tamada
H
,
Inoue
T
,
Shimatani
N
.
Inflammatory pseudotumor of the kidney
.
Int J Urol
.
2004
May
;
11
(
5
):
337
9
.
[PubMed]
0919-8172
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.