Castleman’s disease (CD) is an uncommon type of lymphoproliferative disorder. Its etiology and prevalence are unclear. The retroperitoneum is a very rare site for presentation of the unicentric variant, where it mimics malignant tumors. A 59-year-old man is referred to the urology outpatient clinic for the study of microhematuria found in a routine analysis. CT scan of the abdomen identified a solid, circumscribed mass, measuring 28 × 30 × 31 mm in the left para-aortic zone, with homogeneous contrast enhancement. Excisional surgery and regional lymphadenectomy were performed via laparoscopy. Postoperative course concurred without incidences. Histological diagnosis confirmed unicentric CD, hyaline-vascular type. CD is a rare entity, and the unicentric type presents as an asymptomatic mass. Retroperitoneum is a rare localization, where initial imaging diagnosis is unclear and surgical resection is the preferred treatment.

Keywords:
Castleman’s disease, Laparoscopy, Retroperitoneal tumor, Retroperitoneum
1.
Castleman B, Towne VW: Case records of the Massachusetts General Hospital; weekly clinicopathological exercises; founded by Richard C. Cabot. N Engl J Med 1954; 251: 396–400.
2.
Casper C: The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care. Br J Haematol 2005; 129: 3–17.
3.
Talat N, Belgaumkar AP, Schulte KM: Surgery in Castleman’s disease: a systematic review of 404 published cases. Ann Surg 2012; 255: 677–684.
4.
Liu AY, Nabel CS, Finkelman BS, Ruth JR, Kurzrock R, van Rhee F, et al: Idiopathic -multicentric Castleman’s disease: a systematic literature review. Lancet Haematol 2016; 3:e163–e175.
5.
Franco V: Report of a case of localized Castleman's disease with progression to malignant lymphoma. Am J Clin Pathol 1993; 100: 707–708.
6.
Chan AC, Chan KW, Chan JK, Au WY, Ho WK, Ng WM: Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology 2001; 38: 510–518.
7.
Blute ML Sr, Abramson JS, Cronin KC, Nardi V: Case 5-2017. A 19-year-old man with hematuria and a retroperitoneal mass. N Engl J Med 2017; 376: 684–692.
8.
Lundstedt C, Stridbeck H, Andersson R, Tranberg KG, Andren-Sandberg A: Tumor seeding occurring after fine-needle biopsy of abdominal malignancies. Acta Radiol 1991; 32: 518–520.
9.
Xu J, Zhou BO, Cao HL, Wang BO, Yan S, Zheng SS: Surgical management of isolated retroperitoneal Castleman’s disease: a case report. Oncol Lett 2016; 11: 2123–2126.
© 2018 S. Karger AG, Basel
2018
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.