Due to their immunosuppressed status, solid organ transplant recipients are a special group of patients with an incidence of bladder cancer greater than the rest of the population, especially in the first 6 years after transplantation. Also, treatment with Bacillus Calmette-Guérin, a reference therapy in nonmuscle invasive high-risk bladder cancer, may be less effective in this group of patients and could cause more adverse effects. However, the data published so far and the experience initiated in the Virgen de la Arrixaca Clinical University Hospital do not support these hypotheses.

Keywords:
Nonmuscle invasive bladder cancer, Immunosuppressed, Kidney transplant, Treatment
1.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, et al. EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Eur Urol
. 2017 Mar;71(3):447–61.
2.
Peyromaure M, Zerbib M. T1G3 transitional cell carcinoma of the bladder: recurrence, progression and survival.
BJU Int
. 2004 Jan;93(1):60–3.
3.
Manzanilla-García HA, Mandonado-Ávila M, Aguilar-Barradas J, Lira-Dale A. Inmunoterapia con el bacilo de Calmette-Guérin en el tratamiento del carcinoma superficial de vejiga.
Rev Mex Urol
. 2009;69(6):307–13.
4.
Palou J, Angerri O, Segarra J, Caparrós J, Guirado L, Diaz JM, et al. Intravesical bacillus Calmette-Guèrin for the treatment of superficial bladder cancer in renal transplant patients.
Transplantation
. 2003 Nov;76(10):1514–6.
5.
Wang HB, Hsieh HH, Chen YT, Chiang CY, Cheng YT. The outcome of post-transplant transitional cell carcinoma in 10 renal transplant recipients.
Clin Transplant
. 2002 Dec;16(6):410–3.
6.
Kamal MM, Soliman SM, Shokeir AA, Abol-Enein H, Ghoneim MA. Bladder carcinoma among live-donor renal transplant recipients: a single-centre experience and a review of the literature.
BJU Int
. 2008 Jan;101(1):30–5.
7.
Tomaszewski JJ, Larson JA, Smaldone MC, Hayn MH, Jackman SV. Management of Bladder Cancer following Solid Organ Transplantation.
Adv Urol
. 2011;2011:256985.
8.
Bonarriba CR, de la Cruz-Ruiz M, Gómez-Marqués G. Intravesical Bacillus Calmette-Guérin in immunosuppressed patients with carcinoma in situ.
Nefrologia
. 2013;33(3):429–31.
9.
Palazzetti A, Bosio A, Dalmasso E, Destefanis P, Fop F, Pisano F, et al. De Novo Bladder Urothelial Neoplasm in Renal Transplant Recipients: A Retrospective, Multicentered Study.
Urol Int
. 2018;100(2):185–92.
10.
Vegt PD, van der Meijden AP, Sylvester R, Brausi M, Höltl W, de Balincourt C. Does isoniazid reduce side effects of intravesical bacillus Calmette-Guerin therapy in superficial bladder cancer? Interim results of European Organization for Research and Treatment of Cancer Protocol 30911.
J Urol
. 1997 Apr;157(4):1246–9.
11.
Buzzeo BD, Heisey DM, Messing EM. Bladder cancer in renal transplant recipients.
Urology
. 1997 Oct;50(4):525–8.
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2019
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