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First page of A Comparison of ablation therapy and partial nephrectomy for the Treatment of Renal Cell Carcinoma: A Systematic Review and Meta-analysis

Objective: To conduct a systematic review and meta-analysis comparing ablation therapy (AT) and partial nephrectomy (PN) for renal cell carcinoma (RCC). Methods：This systematic review and meta-analysis were performed in compliance with the PRISMA guidelines. A comprehensive search of the literature published prior to February 1, 2025 was carried out using Pubmed, Embase, Cochran, and Web of Science databases. Stata16 statistical software was utilized for the statistical analysis. Results: This review has analyzed 32 studies involving a total of 6,030 patients. Patients undergoing AT were found to have shorter operation time (OT), reduced length of stay (LOS), lower complication rates (CR), and decreased estimated blood loss (EBL). The study revealed significant differences between AT and PN in terms of overall survival (OS) and recurrence-free survival (RFS). Nevertheless, no statistically significant differences were observed between the two procedures regarding cancer - specific survival (CSS). Conclusion: As a minimally invasive treatment for RCC, AT is superior to PN in terms of OT, EBL, LOS, eGFR, and CR. However, it falls short of PN in OS and RFS.

Journal Section:
Systematic Review
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S. Karger AG, Basel
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2026