Monolayer cell cultures from 15 patients with benign nodular hyperplasia of the prostate and 7 patients with adeno-carcinoma of the prostate were established. Tissue culture methods are described. Cells obtained from carcinoma of the prostate showed a higher plating efficiency than those obtained from hyperplasia of the prostate. Electron microscopic studies revealed in cultures derived from adenocarcinoma of the prostate predominantly one epithelial cell type, which was characterized by close cell growth with many desmosomal junctions and atypical mitochondria. Testosterone in high concentrations decreased the plating efficiency of cells from hyperplasia of the prostate but had no effect in these concentrations on cells from carcinoma of the prostate. In low concentrations testosterone stimulated the growth of cells obtained from carcinomas.

Keywords:
Tissue culture of human prostate
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© 1973 S. Karger AG, Basel
1973
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