Abstract
Renal vasospasm occurring during the agonal phase of many cadaver donors can influence the success of renal homotransplantation because this spasm can persist after nephrectomy and even transplantation. It is of great importance to prevent or to relieve this vasospasm. In dog experiments the vasodilatative effect of 2% novocain, papaverine hydrochloride and phenoxybenzamine was examined performing angiograms. Vasospasm, induced by hemorrhagic shock, could fairly be influenced by the application of novocain. Papaverine hydrochloride and phenoxybenzamine showed a minor vasodilatative effect in the isolated vasospastic kidney. The preventive effect of phenoxybenzamine, given before the beginning of shock, justifies the application of this substance to all cadaver donors to prevent vasospasm.